体成分与胰岛β细胞功能变化对生育期正常糖代谢肥胖女
性骨密度的影响
严孙杰;李美蓉;沈喜妹;杨立勇;张松菁;易如海;顏晓芳
【期刊名称】《中华全科医师杂志》 【年(卷),期】2009(008)012
【摘要】Objective To investigate effects of changes in body composition and pancreas islet β-cell function on bone mineral density(BMD)in obese women with normal glucose metabolism at child-bearing age.Methods Ninety-five obese women with normal blood glucose at child-bearing age were recruited for the study,20 in non-obese group with body mass index(BMI)less than 23,20 in overweightgroup with BMI equal to or more than 23 and less than 25.28 in obesity Ⅰ group with BMI equal to or more than 25 and less than 30.and 27 in obesity Ⅱ group with BMI equal to or more than 30.Their BMD,body fat and lean mass
were
measured
with
by
dual
energy
X-ray
absorptiometer(DEXA),and intravenous -glucose tolerance
test(IVGTT)was performed.Area under the Curve of insulin(AUCins)and acute jnsulin response(AIR)phase were calculated to assess their early insulin secretion.Homeostasis model assessment β-cell function index(HOMA2-%B)and
homeostasis
model
insulin
resistance
index(HOMA2-IR)were used to assess their β-cell function and insulin resistance.Results Fat and lean mass in the upper and lower
体成分与胰岛β细胞功能变化对生育期正常糖代谢肥胖女性骨密度的影响
