Preparation of Anti-Idiotypic Antibody against Avian Influenza Virus Subtype H9

Preparation of Anti-Idiotypic Antibody against

Avian Influenza Virus Subtype H9

Baoquan Li;Jun Peng;Zhongxiang Niu;Xunhe Yin;Faxiao Liu

【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2005(002)002

【摘要】To generate monoclonal anti-idiotypic antibodies (mAb2) against avian influenza virus subtype H9 (H9 AIV),BALB/c mice were immunized with purified chicken anti-H9-AIV IgG and the splenocytes of immunized mice were fused with myeloma cells NS-1. Hybridoma cells were screened by indirect enzyme-linked immunosorbent assays with both chicken and rabbit anti-H9-AIV IgG as coating antigens. One hybridoma cell clone secreting monoclonal antibody against idiotypes shared by both chicken and rabbit anti-H9-AIV IgG was established. Experiments demonstrated the mAb2 was able to inhibit the binding of hemagglutinin to anti-H9-AIV IgG and to induce chickens to generate hemagglutination inhibition antibodies, indicating this anti-species-sharing-idiotypic antibody bore the internal image of hemagglutinin on avian influenza virus. Cellular & Molecular Immunology. 2005;2(2):155-157.

【总页数】3页(155-157)

【关键词】avian influenza virus, anti-idiotypic antibody, idiotype 【作者】Baoquan Li;Jun Peng;Zhongxiang Niu;Xunhe Yin;Faxiao Liu

【作者单位】College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China;College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China;College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China;College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China;College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cellular-molecular-immunology_thesis/0201224032107.html 【相关文献】

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