精氨洛芬治疗膝骨关节炎和类风湿关节炎的疗效和安全性的多中心随

精氨洛芬治疗膝骨关节炎和类风湿关节炎的疗效和安全性

的多中心随机开放对照研究

冷晓梅;古洁若;黄建林;韩星海;赵东宝;戴生明;韩少梅;徐涛;张奉春;粟占国;张学武;吴东海;周惠琼;孙凌云;杨岫岩;梁柳琴

【期刊名称】《中华风湿病学杂志》 【年(卷),期】2009(013)003

【摘要】Objective To compare the clinical efficacy of ibuprofen arginate,a new nonsteroidal antiinflammatory drug,with that of ibuprofen,in patients with rheumatoid arthritis or knee osteoarthritis and

to

evaluate

the

safety

and

tolerability

of

ibuprofen

argihate.Methods This is a muhicenter,random,open,active comparator-controlled,parallel clinical trail in which 171 patients with rheumatoid arthritis or knee osteoarthritis were enrolled.Patients were randomized to 2 groups:400 mg of ibuprofen arginate three times daily and 400 mg of ibuprofen three times daily respectively.Clinical efficacy and safety were evaluated after 4-week treatment.Results Ibuprofen arginate,at dosages of 400 mg three times daily,had shown significant efficacy in relieving pain,tenderness and swelling of joints and there was no significant difference when compared to that of ibuprofen.There was no difference in clinical adverse effects between the two groups and no serious adverse effects were repofled.But ibuprofen arginate could initiate effectiveness more rapidly than ibuprofen in both rheumatoid