糖皮质激素受体基因多态性与重症肌无力的关系
王莉莉;刘建军;沈定国;谢琰臣;侯世芳;冯凯;殷剑;许贤豪;李尊波;王英鹏;熊葶
【期刊名称】《中华医学杂志》 【年(卷),期】2009(089)043
【摘要】Objective To investigate the association of two glucocorticoid receptor (GR) polymorphisms (Bcl I ,ER22/23EK) with Myasthenia Gravis (MG). Methods The genotypes of GR in 61 MG patients (MGG) and 57 age and gender -matched healthy controls (HCG) were determined by polymerase chain reaction and nucleotide sequence determination. Results The frequencies of three genotypes (GG,CG,CC) in Bcl I were 3.3% ,34. 4% ,62. 3% in MGG and 3.5% ,38.6% ,57.9% in HCG respectively. The difference in the distribution of genotypes between MGG and HCG was statistically insignificant (P=0.887). The frequencies of G and C allele were 20.5% vs 79.5 % in MGG, and 22.8% vs 77.2% in HCG. The difference in the distribution of alleles between MGG and HCG was statistically insignificant (P=0.968). The genotype frequencies in two groups were both in Hardy-Weinberg equilibrium (P > 0.05).The genotypes of ER22/23EK in MGG and HCG were all GG and no mutation was detected. Conclusion Bcl I and ER22/23EK polymorphisms of GR have no definite relationship with the risk of MG.%目的 探讨糖皮质激素受体(GR)Bcl I、ER22/23EK基因多态性与重症肌无力(MG)的关系.方法 应用PCR产物直接测序方法检测MG患者组(MGG)61例和性别、年龄相匹配的健康对
糖皮质激素受体基因多态性与重症肌无力的关系
