A high-fat diet reverses improvement in glucose tolerance induced by duodenal-jejunal bypa

A high-fat diet reverses improvement in glucose tolerance induced by duodenal-jejunal bypass in

type 2 diabetic rats

LIU Shao-zhuang;SUN Dong;ZHANG Guang-yong;WANG Lei;LIU Teng;SUN Yu;LI Ming-xia;HU San-yuan

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2012(125)005

【摘要】Background Bariatric surgery offers successful resolution of type 2 diabetes mellitus (T2DM).However,recurrence of T2DM has been observed in a number of patients with initial resolution after bariatric surgery.This study aimed to induce reversal of the improvement of diabetes in T2DM rats after duodenal-jejunal bypass (DJB),and identify the effects of weight changes and gut hormones that might be involved.Methods DJB surgery was performed in two T2DM rat models (n=20 for each group):non-obese Goto-Kakizaki (GK) rats,and moderately-obese T2DM rats induced by a combination of a high-fat diet (HFD) and low-dose streptozotocin (HS rats).The controls were sham-operated and non-treated rats.All rats were then randomly divided into HFD- and low-fat diet (LFD)-fed groups.Glucose tolerance,insulin

tolerance,glucose-stimulated

insulin,glucagon-like

peptide-1 (GLP-1) and peptide YY (PYY) secretion,food intake and body weight were measured and compared with controls.Results DJB surgery