Preliminary study on association between toxoplasmosis and breast cancer in Iran

Preliminary study on association between toxoplasmosis and breast cancer in Iran

Narges;Kalantari;Salman;Ghaffari;Masomeh;Bayani;Maryam;Mitra;Elmi;Daryush;Moslemi;Novin;Nikbakhsh;Fariedh;Ghavipanjeh;

【期刊名称】《亚太热带生物医学杂志：英文版》 【年(卷),期】2015(000)001

【摘要】Objective:To investigate the possible association between Toxoplasma gondii(T.gondii)infection and breast cancer by examining the seropositivity and serointensity rate of anti-T gondii antibodies in breast cancer patients and healthy volunteers.Methods:This study was carried out on 66 women with breast cancer which consists of 29 newly diagnosed patients(Group 1) and 37 cases undergoing treatment and regular checkups(Group 2).Also,60 healthy women(Group 3) with no history of cancer confirmed by clinical examination and imaging participated in this study.The participants were tested for T.gondii immunoglobulin G(IgG) and immunoglobulin M(IgM) antibodies by enzyme-linked immunoassays.Results:The mean age of Groups 1.2 and 3

were

43.3±6.8,41.8±5.5

and

42.3±4.9.respectively(P=0.72).Overall.104(82.5%) and 8(6.3%) out of 126 women

were

positive

for

anti-T

gondii

IgG

and

IgM

antibodies,respectively.Higher seropositivity rate of anti-T.gondii antibodies(IgG) was seen in breast cancer patients(86.4%) compared