癌胚抗原相关细胞黏附分子和人胸肾表达趋化因子在婴幼儿血管瘤组

癌胚抗原相关细胞黏附分子和人胸肾表达趋化因子在婴幼

儿血管瘤组织中的表达

徐广琪;吕仁荣;霍然;郭璇

【期刊名称】《中华整形外科杂志》 【年(卷),期】2010(026)003

【摘要】Objective To examine the expression of CEACAM-1 and CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma. Methods The expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas, involuting hemangiomas, involuted hemangiomas. The mean optical density was measured by image analysis system. Results The expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative, while it was strong in involuting hemangiomas and positive in the involuted stage. The differences between different stages had a statistically significance (P <0. 05). The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas, positive in involuting hemangiomas and strong in the involuted stage. The differences between different stages had a statistically significance (P <0. 05). Conclusions CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma.%目的 检测癌胚抗原相关细胞黏附分子(CEACAM-1)和人胸肾