生长激素在多囊卵巢综合征促排卵中的作用
王颖;李美芝;杨池荪;王振红;姜颜彬
【期刊名称】《中华妇产科杂志》 【年(卷),期】2001(036)001
【摘要】Objective To study the effect of growth hormone (GH) on the outcome of ovulation induction in patients with polycystic ovary syndrome (PCOS). Methods We examined serum sex hormone， GH and
insulin
like
growth
factor-Ⅱ(IGF-Ⅱ)
basal
levels
by
radioimmunoassay in 130 PCOS patients and 107 normal women. In addition, we observed the effect of GH on the outcome of ovulation induction in 7 poor responders to human menopausal gonadotropin (hMG) treatment. Results The mean serum GH level is (2.50±1.33) μg/L and (1.04±0.47) μg/L respectively in nonobese and obese PCOS patients which were significantly lower than those in controls ［(5.30±2.26) μg/L, (2.95±1.49) μg/L respectively, P<0.05］. The mean serum IGF-Ⅱ level is (136±27) nmol/L in the obese PCOS patients, significantly greater than those in nonobese PCOS and controls (P<0.05). When we used GH with hMG in 7 poor responders, the total amount of hMG required decreased from 1 to 12 amples and the duration of treatment shortened as compared with hMG alone. Conclusion
There is
abnormal GH secretion in patients with PCOS, GH may improve the outcome of ovulation induction by gonadotropin.%目的 探讨生长激素
生长激素在多囊卵巢综合征促排卵中的作用
