Association of TNF-α promoter polymorphisms with the outcome of persistent HBV infection

Association of TNF-α promoter polymorphisms with the outcome of persistent HBV infection in a

northeast Chinese Han population

Bing Qiu;Xi Wang;Peiyi Zhang;Chunlin Shi;Jiye Zhang;Wenliang Qiu;Wenduo Wang;Dongfu Li

【期刊名称】《生物化学与生物物理学报：英文版》 【年(卷),期】2012(044)008

【摘要】Tumor necrosis factor-α (TNF-α) plays an important role in the pathogenesis and clinical outcome of chronic hepatitis B virus (HBV) infection.The objective of this study was to evaluate the relationship between functional polymorphisms of TNF-α and different outcomes of persistent HBV infection in a northeast Chinese Han population.Here 189 HBV spontaneously recovered subjects (SR),571 HBV-infected patients including 180 chronic hepatitis B (CHB),196 liver cirrhosis (LC),and 195 hepatocellular carcinoma (HCC) individuals were enrolled in this study.All the samples were genotyped for TNF-α-857C/T and -863C/A using the polymerase chain reaction-restriction fragment length polymorphism method.The frequency of -857CC genotype was significantly higher in CHB and LC individuals compared with that of SR subjects (P =0.03,OR =1.57,95％ CI 1.04-2.39 and P =0.03,OR =1.57,95％ CI 1.04-2.35,respectively).A significant difference in the distribution of the allele--857C was observed for both CHB vs.SR (P =0.01,OR =1.52,95％

CI 1.08-2.13) and LC vs.SR (P =0.02,OR =1.47,95％ CI 1.06-2.04) cohorts.In addition,the frequency of -863AA genotype was significantly higher in CHB and LC patients than that of SR subjects (P =0.01,OR =3.90,95％ CI 1.35-11.23 and P =0.01,OR =3.83,95％CI 1.34-10.96,respectively),and allele-863A frequency was significantly more common in CHB,LC,and HCC cohorts than that of SR controls (P =0.004,OR =1.72,95％ CI 1.19-2.50; P =0.001,OR =1.81,95％ CI 1.26-2.61 and P =0.001,OR =1.90,95％ CI 1.33-2.73,respectively).Our data also revealed that haplotype CA was strongly associated with persistent HBV infection.These results suggest an association between the TNF-α promoter variants and different outcomes of persistent HBV infection in the studied population. 【总页数】7页(712-718) 【关键词】

【作者】Bing Qiu;Xi Wang;Peiyi Zhang;Chunlin Shi;Jiye Zhang;Wenliang Qiu;Wenduo Wang;Dongfu Li

【作者单位】Department of Gastroenterology, Heilongjiang Province Hospital, Harbin 150036, China;Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;Department of Gastroenterology, Heilongjiang Province Hospital, Harbin 150036, China;Department of Gastroenterology, Heilongjiang Province

Hospital,

Harbin

150036,

China;Department

of

Gastroenterology, Heilongjiang Province Hospital, Harbin 150036, China;Department of Gastroenterology, Heilongjiang Province Hospital, Harbin 150036, China;Department of Gastroenterology, Heilongjiang Province

Hospital,

Harbin

150036,

China;Department

of

Gastroenterology, The Second Hospital of Jilin University, Changchun 130041, China 【正文语种】中文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_acta-biochimica-biophysica-sinica_thesis/0201254942305.html 【相关文献】

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