免疫性血小板减少症患者外周血CD4+CD25+调节性T细
胞变化的临床意义
李元媛;邓之奎;刘小宁;曹维克;于亮
【期刊名称】《江苏医药》 【年(卷),期】2013(039)006
【摘要】Objective To explore the clinical significance of CD4+ CD25+ regulatory T cells change in peripheral blood of patients with immune thrombocytopenia(ITP). Methods CD4+ CD25+ regulatory T cells in peripheral blood were examined by flow cytometry in ITP patients (group A, 62 cases) before and after different treatments and 35 healthy people (group B). The Foxp3 mRNA expression in peripheral blood was detected by RT-PCR. Results Compared with group B, the percentage of CD4+CD25+ regulatory T cells in group A was higher[(9. 60 ±4. 15)% vs. (16. 56± 5. 68) %] ,but the percentages of CD4+ Foxp3+ and CD4+ CD25 + Foxp3+ regulatory T cells were lower [(3.88±1.34)% vs. (1.98±1. 53)%,and (2.72 ± 0.93)% vs. (1.38± .98)%] before treatment (P<0.05).The percentage of CD4+CD25+ regulatory T cells in group A was (10. 72 ±5. 15)%, which was lower than that before(P<0. 05). The percentage of CD4+ CD25+ regulatory T cells was higher in the patients treated with Rituximab combined with gamma globulin than that in those treated with other different treatments(P<10. 05). The level of Foxp3 mRNA was lower in group A before treatment than that in group B, which was
免疫性血小板减少症患者外周血CD4+CD25+调节性T细胞变化的临床意义
