Evaluation of Basal Serum Adrenocorticotropic Hormone and Cortisol Levels and Their Relati

Evaluation of Basal Serum Adrenocorticotropic

Hormone and Cortisol Levels and Their Relationship with Nonalcoholic Fatty Liver Disease in Male Patients with Idiopathic Hypogonadotropic

Hypogonadism

Wen-Bo Wang;Fei She;Li-Fang Xie;Wen-Hua Yan;Jin-Zhi Ouyang;Bao-An Wang;Hang-Yun Ma

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)010

【摘要】Background:Prolonged gonadal hormone deficiency in patients with idiopathic hypogonadotropic hypogonadism (IHH) may produce adverse effects on the endocrine homeostasis and metabolism.This study aimed to compare basal serum adrenocorticotropic hormone (ACTH) and cortisol levels between male IHH patients and healthy controls.Moreover,this study compared the basal hypothalamic-pituitary-adrenal (HPA) axis in patients with and without nonalcoholic fatty liver disease (NAFLD),and also evaluated the relationship between basal HPA axis and NAFLD in male IHH patients.Methods:This was a retrospective case-control study involving 75 Chinese male IHH patients (mean age 21.4 ± 3.8 years,range 17-30 years) and 135 healthy controls after matching for gender and age.All subjects underwent physical examination and blood testing for serum testosterone,luteinizing