产气荚膜梭菌肠毒素羧基端多肽片段在肿瘤治疗中的研究
进展
陈虹
【期刊名称】《肿瘤研究与临床》 【年(卷),期】2016(028)005
【摘要】目前大约有85％的恶性肿瘤来源于上皮细胞,一种针对上皮细胞的治疗方法已经成为肿瘤治疗的焦点.Claudin-3、Claudin-4作为紧密连接结构的重要组分,在恶性肿瘤中大量表达,而产气荚膜梭菌肠毒素(CPE)作为Claudin-3、Claudin-4的特异性结合配体,在肿瘤的治疗中有着重要的意义.但是CPE具有较大的肠毒性,临床应用大大受限.CPE羧基端多肽片段(C-CPE)是CPE的特异性结合域,具有CPE的特异性而没有肠毒性.文章对目前C-CPE在肿瘤治疗方面的研究进展进行综述.%There are approximately 85 ％ of malignant tumors derived from epithelial cells,and a therapeutic method of epithelial cells has become the focus of cancer treatment.Claudin-3 and Claudin-4 as important components of the tight junction structure are abundantly expressed in malignant tumors,and the clostridium perfringens enterotoxin (CPE) as Claudin-3 and Claudin-4 specific binding ligand has
important
significances
of
the
in large
the
treatment
of
tumors.However,because intestinal toxicity,clinical
application of CPE has been limited greatly.Carboxyl peptide fragment of CPE (C-CPE) is a specific binding domain of CPE,which has specificity without intestinal toxicity.This review will present some advances of C-
产气荚膜梭菌肠毒素羧基端多肽片段在肿瘤治疗中的研究进展
