骨碱性磷酸酶、血25-羟维生素D3联合骨密度对小儿维生
素D缺乏性佝偻病的诊断价值
欧丽黎;李吉华
【期刊名称】《医学综述》 【年(卷),期】2018(024)007
【摘要】Objective To investigate the diagnostic value of serum 25 hydroxyvitamin D3[25-(OH) D3],bone alkaline phosphatase(B-ALP) levels and bone mineral density index for vitamin D deficiency rickets (rickets) in children. Methods From Jan. 2014 to Jun. 2016, 107 cases of suspected rickets in children in People's Hospital of Yicheng City were selected as the research objects. The blood 25-(OH) D3,B-ALP, calcium,phosphorus levels and bone mineral density were compared between the group with and without rickets, and the diagnostic efficacies of 25-(OH) D3,B-ALP level and bone mineral density respectively and combined for rickets were calculated. Results Among the 107 cases, 41 cases were detected rickets(38. 32％). The sensitivity, specificity and accuracy and positive predictive value of 25-(OH) D3 + B-ALP + bone density were 82. 93％, 93. 46％and 100. 00％,which were significantly higher than 25-(OH) D3(68. 29％, 85. 98％, 93. 33％),B-ALP (56. 10％,78. 50％,82. 14％) and bone density (51. 22％,74. 77％,75. 00％) respectively. Conclusion 25-(OH) D3 is an important index for the diagnosis of rickets in children, and its combination with B-ALP, bone
mineral density can improve the accuracy of diagnosis.%目的探讨血25-羟维生素D3[25-(OH) D3]、骨碱性磷酸酶(B-ALP)联合骨密度对小儿维生素D缺乏性佝偻病(佝偻病)的诊断价值.方法选取2014年1月至2016年6月宜城市人民医院收治的疑似佝偻病儿童107例作为研究对象,比较有无佝偻病组的血25-(OH) D3、B-ALP、钙、磷水平和骨密度.并计算血25-(OH) D3、 B-ALP和骨密度及三者联合诊断佝偻病的诊断效能.结果107例儿童中,检测出佝偻病患儿41例(38. 32％); 25-(OH) D3 + B-ALP +骨密度联合诊断佝偻病的灵敏度、准确度、阳性预测值(82. 93％、93. 46％、100. 00％)均明显高于25-(OH) D3(68. 29％、85. 98％、93. 33％)、B-ALP(56. 10％、78. 50％、82. 14％)和骨密度(51. 22％、74. 77％、75. 00％)单独诊断.结论25-(OH) D3是诊断小儿维生素D缺乏性佝偻病的重要指标,联合B-ALP、骨密度可提高诊断的准确性.
【总页数】4页(1449-1452)
【关键词】维生素D缺乏性佝偻病;骨碱性磷酸酶;25-羟维生素D3;骨密度;诊断价值
【作者】欧丽黎;李吉华
【作者单位】宜城市人民医院儿科, 湖北 宜城 441400;宜城市人民医院儿科, 湖北 宜城 441400 【正文语种】中文 【中图分类】R153.2 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_medical-
recapitulate_thesis/0201252650885.html 【相关文献】
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2.不同年龄段儿童25-羟维生素D3及骨碱性磷酸酶水平与佝偻病的关系分析 [J], 吕莉; 魏琼; 陈丽颖; 陈思思
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骨碱性磷酸酶、血25-羟维生素D3联合骨密度对小儿维生素D缺乏性佝偻
