Method of using human receptor protein 4-1BB
申请(专利)号： JP20000539866
专利号： JP2002531376A 主分类号： A61K39/395
申请权利人： アドバンスト リサ
ーチ アンド テクノロジー インスティテュート,インコーポレイティド 公开国代码： JP 优先权国家： US
摘 要：
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The nature and importance of the H4-1BB molecule provides the ligands and related co-stimulatory molecules the ability to
enhance or suppress T-cell activation and proliferation. By treating T-cells that have
申请日： 1999-01-14 公开公告日： 2002-09-24
分类号： A61K39/395;
A61K38/00; A61K45/00; A61K45/06; A61P3/10; A61P29/00; A61P37/02; A61P43/00; C07K14/705; C07K16/28; C07K19/00; C12N5/10; C12P21/08; G01N33/53; G01N33/577 发明设计人： クワン,ビヤング エ
ス.
申请国代码： JP
优先权： 19980114 US
09/007,097
摘 要 附 图：
expressed receptor protein H4-1BB with one of the four anti-H4-1BB monoclonal antibodies disclosed herein activation or inhibition of the immune response is seen. Also disclosed herein is cDNA for the human receptor H4-1BB. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from murine cDNA 4-1BB. A
fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB was developed. It comprises the extracellular portion of the receptor
protein H4-1BB and a detection protein, alkaline phosphatase, bound to the
portion of the receptor protein H4-1BB. B-cells that have expressed a ligand to receptor protein H4-1BB can be treated with cells that have expressed receptor protein H4-1BB and B-cell proliferation may be induced. The use of H4-1BB to block H4-1BB ligand binding has practical application in the suppression of the immune system during organ
transplantation or against autoimmune diseases including diabetes, rheumatoid arthritis, and lupus. Other applications of this technology include the development of therapeutic methods for the treatment of HIV-1 infected individuals, and the treatment of cancerous tumors. 主权项：
【請求項1】 第1 のH4-1BBレセプターのリガンドが少なくとも1 つのT 細胞と接触し、これによりそれを活性化させるように、有効量の前記レセプターのリガンドを投与することを含んでなる、T 細胞の
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Method of using human receptor protein 4-1BB
