多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的临床研究
王雪
【期刊名称】《中国继续医学教育》 【年(卷),期】2015(000)014
【摘要】目的：探讨多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的的临床疗效和安全性。方法78例阿尔茨海默病患者随机分为观察组与对照组两组各39例，观察组患者采用多奈哌齐联合盐酸美金刚治疗，对照组患者采用多奈哌齐治疗，采用AD 评估量表-认知部分（ADAS-cog）、简易智能精神状态检查量表（MMSE）和日常生活活动能力量表（ADL）评定患者治疗前后的临床效果。结果治疗后，两组患者ADAS-cog、MMES和ADL量表评分与治疗前相比均有所改善（P＜0.05）；观察组患者改善效果好于对照组（P＜0.05）。两组不良反应发生情况相比差异无统计学意义（P＞0.05）。结论多奈哌齐联合盐酸美金刚治疗阿尔茨海默病疗效显著，能显著改善患者的认知功能和行为能力，并且具有良好的安全性。%Objective To explore the clinical effects and security of donepezil combined with memantine in the treatment of alzheimer’s disease. Methods78 cases of Alzheimer's disease patients were randomly divided into observation group and control group 39 cases in each group, the patients in the observation group with donepezil and memantine hydrochloride in the treatment and control group were treated with donepezil, table - cognitive (ADAS-cog), Mini Mental State Examination (MMSE) and activities of daily living ability scale (ADL) before and after treatment in patients with the clinical effect
多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的临床研究
