Photo-controlled release of paclitaxel and model
drugs from RNA pyramids
Congcong Xu;Hui Li;Kaiming Zhang;Daniel W.Binzel;Hongran Yin;Wah Chiu;Peixuan Guo
【期刊名称】《纳米研究（英文版）》 【年(卷),期】2019(012)001
【摘要】Stimuli-responsive release of drugs from a nanocarrier in spatial-,temporal-,and dosage-controlled fashions is of great interest in the pharmaceutical industry.Paclitaxel is one of the most effective and popular chemotherapeutic drugs against a number of cancers such as metastatic or nonmetastatic breast cancer,non-small cell lung cancer,refractory ovarian cancer,AIDS-related Kaposi's sarcoma,and head and neck cancers.Here,by taking the advantage of RNA nanotechnology in biomedical and material science,we developed a three-dimensional
pyramid-shaped
RNA
nanocage
for
a
photocontrolled release of cargo,using paclitaxel as a model drug.The light-triggered release of paclitaxel or fluorophore Cy5 was achieved by incorporation
of
photocleavable
spacers
into
the
RNA
nanoparticles.Upon irradiation with ultraviolet light,cargos were rapidly released (within 5 min).In vitro treatment of breast cancer cells with the RNA nanoparticles harboring photocleavable paclitaxel showed higher cytotoxicity as compared to RNA nanoparticles without the
photocleavable spacer.The methodology provides proof of concept for the application of the light-triggered controlled release of drugs from RNA nanocages. 【总页数】8页(41-48) 【关键词】
【作者】Congcong Xu;Hui Li;Kaiming Zhang;Daniel W.Binzel;Hongran Yin;Wah Chiu;Peixuan Guo
【作者单位】Center for RNA Nanobiotechnology and Nanomedicine; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and James Comprehensive Cancer Center, The Ohio State University,
Columbus,
Ohio
43210,
USA;Center
for
RNA
Nanobiotechnology and Nanomedicine; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA;Departments of Bioengineering， Microbiology and Immunology, and James H. Clark Center, Stanford University, Stanford, CA 94305, USA;Center for RNA Nanobiotechnology and Nanomedicine; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and James Comprehensive Cancer Center, The Ohio State
University, Columbus, Ohio 43210, USA;Center for RNA
Nanobiotechnology and Nanomedicine; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA;Departments of Bioengineering， Microbiology and Immunology, and James H. Clark Center, Stanford University, Stanford, CA 94305, USA;SLAC National Accelerator Laboratory, Stanford University,
Menlo
Park,
CA
94025,
USA;Center
for
RNA
Nanobiotechnology and Nanomedicine; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA 【正文语种】英文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_nano-research-english_thesis/0201271732641.html 【相关文献】
1.Photo-controlled release of paclitaxel and model drugs from RNA pyramids [J], Congcong Xu[1]; Hui Li[1]; Kaiming Zhang[2]; Daniel
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2.The Controlled-releasing Drug Implant based on the Three Dimensional Printing Technology： Fabrication and Properties of Drug Releasing in vivo [J], WU Weigang; ZHENG Qixin; GUO Xiaodong; HUANG Weidong
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4.Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release [J], Sheng Huang[1]; Jing Liu[2]; Qian He[1]; Hongli Chen[1]; Jiabin Cui[1]; Suying Xu[1]; Yuliang Zhao[2]; Chunying Chen[2]; Leyu Wang[1]
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Photo-controlled release of paclitaxel and model drugs from RNA pyramids
