Significance of Aspergillus spp.isolation from lower respiratory tract samples for the dia

Significance of Aspergillus spp.isolation from lower respiratory tract samples for the diagnosis and prognosis of invasive pulmonary aspergillosis in

chronic obstructive pulmonary disease

HE Hang-yong;CHANG Shuo;DING Lin;SUN Bing;LI Fang;ZHAN Qing-yuan

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2012(125)017

【摘要】Background Chronic obstructive pulmonary diseases (COPD) is an

emerging

population

at

risk

for

invasive

infection

of

Aspergillus.Isolation of Aspergillus from lower respiratory tract (LRT) samples is important for the diagnosis of invasive pulmonary aspergillosis (IPA).The purpose of this study was to investigate the value of Aspergillus isolation from LRT samples for the diagnosis and prognosis of IPA in COPD population.Methods Clinical record with Aspergillus spp.isolation in COPD and immunocompromised patients was reviewed in a retrospective study.Patients were categorized and compared according to their severity of illness (admitted to general ward

or

ICU)

and

immunological

function

(COPD

or

immunocompromised).Results Multivariate statistical analysis showed that,combined with Aspergillus spp.isolation,APACHE Ⅱ scores ＞18,high cumulative doses of corticosteroids (＞350 mg prednisone or equivalent dose) and more than four kinds of broad-spectrum