联合应用肿瘤标记物在胰腺癌诊断中的意义
曾勇;宁立芬;方江;冯茂辉;袁先厚
【期刊名称】《中华实验外科杂志》 【年(卷),期】2010(027)004
【摘要】Objective To investigate the significance of combined detection of cancer antigen 199 (CA 199 ), CA 242 and carcinoembryonic antigen (CEA) in the diagnosis and prognosis of the carcinoma of pancreas. Methods Chemical luminous technique was used in detecting the expression level of CA 199, CA 242 and CEA in the serum of 50 patients with pancreatic carcinoma (pancreatic carcinoma group), 42 patients with benign pancreatic disease (benign disease group) and 60 healthy people (healthy control group) separately. Results The levels of the 3 tumor markers [CA 199:(226.26±42.06) vs (52.26 ± 15.32) or (10.12 ± 6.35) U/ml, CA 242 : (68.82 ± 7.63) vs (18.25 ± 3.58) or (9.86± 4.67) U/ml, CEA: (9.63 ±5.84) vs (4.16 ±2.58) or (2.25±1.24) μg/L] in the pancreatic carci-noma group were significantly higher than those in other two groups (all P < 0.05 ). The positive rate of 3 tumor markers (CA 199: 82.61%, CA 242: 76.09%, CEA: 60.87% ) in the pancreatic carcinoma group was significantly higher than those in other two groups (all P < 0.05). The rate of accuracy of the combined detection was 97.83%. The level of CA 199 was positively correlated with the stage of pancreatic carcinoma, but negatively with the life span of the patients. Conclusion
联合应用肿瘤标记物在胰腺癌诊断中的意义
