ULBP ANTIBODIES
申请(专利)号： US20100862629
专利号： US2011281789A1 主分类号： C07K14/435
申请日： 2010-08-24 公开公告日： 2011-11-17
分类号： C07K14/435;
申请权利人： 公开国代码： 优先权国家： DAVID J.
COSMAN; JURGEN MULLBERG; WILLIAM C. FANSLOW, III; MAREK KUBIN; RICHARD JEFFREY ARMITAGE US US
发明设计人： 申请国代码： 优先权： C12N15/63; C12N5/10; C12N1/19; A61P31/12; C12N1/15; G01N33/574; A61K38/17; A61P35/04; C12N15/11; C12N1/21 DAVID J. COSMAN;
JURGEN MULLBERG; WILLIAM C. FANSLOW, III; MAREK KUBIN;
RICHARD JEFFREY ARMITAGE
US
20020805 US
21250702; 20100824 US 86262910; 20080804 US 22149008; 20061213 US 63896606; 20040623 US 87586904; 20000322 US 53285600; 19981217 US 9827048;
19980715 US 9294698; 19971217 US 6985797
摘 要：
The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas.
Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare
antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a
malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity. 主权项：
1. An isolated polynucleotide molecule selected from the group consisting of: 摘 要 附 图： 权 利 要 求 说 明 书 【ULBP ANTIBODIES】的权利说明书内容是......请下载后查看
ULBP ANTIBODIES
