汉族459例结核病易感基因多态性与临床特征的相关性
刘轾彬;刘一典;唐神结;郑瑞娟;肖和平;沙巍;张青;吴福蓉;孙华;张忠顺;崔海燕
【期刊名称】《中华结核和呼吸杂志》 【年(卷),期】2011(034)012
【摘要】Objective To study the correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of tuberculosis in Han population.Methods Four hundred and fifty-nine tuberculosis inpatients of Han population in Shanghai Pulmonary Hospital from Jan 2007 to Dec 2008 were recruited.The clinical characteristics of tuberculosis ( gender,fever,extent of lesions,cavity formation,hemoptysis,initial
treatment
and
retreatment)
were
observed.The polymorphisms of VDR gene (variants in Fok Ⅰ and Taq 1 ),NRAMP1 gene (variants in INT4,D543N and 3 UTR),MBL gene (variants in HL,YX and QP) and IFNG gene (variants in 874AT) were genotyped by a variety of SNP genotyping techniques.The correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of the disease was analyzed by ANOVAs.Results The frequency of CC,CT and TT variants of Fok Ⅰ in VDR gene in cases with fever were 54.7％ (29/53),13.2％ (7/53) and 32.1％ ( 17/53),respectively,compared to40.6％ (52/128),30.5％ (39/128) and 28.9％ (37/128)in cases without fever,the difference being significant ( x2 =6.183,P ＜ 0.05 ).In patients with CT variants,15.2％ (7/46) had
汉族459例结核病易感基因多态性与临床特征的相关性
