Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-fl

Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora

and fermentation in term infants

BEN Xiao-ming 贲晓明;ZHOU Xiao-yu 周晓玉;ZHAO Wei-hua 赵卫华;YU Wen-liang 喻文亮;PAN Wei 潘伟;ZHANG Wei-li 张伟利;WU Sheng-mei 吴圣楣;Christien M.Van Beusekom;Anne Schaafsma

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2004(117)006

【摘要】Background Oligosaccharides in human milk may protect infants by improving the intestinal micro-flora and fermentation. This study was to investigate effects of infant formula milk consisting of galacto-oligosaccharide (GOS) on intestinal microbial populations and the fermentation characteristics in term infants in comparison with that of human milk. Methods The test formula (Frisolac H, Friesland, Netherland) was supplemented with GOS at a concentration of 0.24 g/dl. Human milk and another formula without oligosaccharides (Frisolac H, Friesland, Netherland) were used as positive and negative control respectively. Growth, stool characteristics, and side effects of the recruited infants were recorded after 3 and 6 months' follow-up, and the fecal species were collected for the analysis of intestinal micro-flora, short chain fatty acid (SCFA) and pH.Results At the end of 3- and 6-month feeding period, intestinal Bifidobacteria and Lactobacilli were