表皮生长因子受体、KRAS及BRAF基因突变与非小细胞
肺癌临床病理特征的关系
高宁;郗彦凤;王跃华;李亚玲;郭江红;王晋芬
【期刊名称】《肿瘤研究与临床》 【年(卷),期】2015(027)008
【摘要】Objective To investigate the epidermal growth factor receptor (EGFR),KRAS and BRAF mutations and their correlation with clinicopathological characteristics in non-small-cell lung cancer (NSCLC).Methods The mutations of exon 18,exon 19,exon 20 and exon 21 of the EGFR,codon 12,codon 13 of the KRAS and codon 600 of the BRAF gene in 143 cases of NSCLC were detected by gene sequencing.The
relationship
between
the
mutations
and
clinicopathological features was analyzed by SPSS 16.0.Results EGFR mutation was detected in 57 cases (39.9 ％),including 2 mutations in exon 18,25 in exon 19,3 in exon 20,24 in exon 21 and 3 multiple point mutations.KRAS mutation was found in 25 cases (17.5 ％),including 23 in codon 12 and 2 in codon 13.BRAF V600E mutation was detected only in 2 cases (1.4 ％).No patient harboring multiple EGFR,KRAS and BRAF mutations
was
found.EGFR
mutation
rate
was
related
to
gender,smoking history,histological types,differentiation and tumor size (P ＜ 0.05).However,no relationship was found among lymph node metastasis,pTNM stage and EGFR mutation (P ＞ 0.05).There was no
表皮生长因子受体、KRAS及BRAF基因突变与非小细胞肺癌临床病理特征的关系
