Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-media

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing

regulatory T cells

Zhijian Cai;Wei Zhang;Fei Yang;Lei Yu;Zhou Yu;JihHung Pan;Lie Wang;Xuetao Cao;Jianli Wang

【期刊名称】《细胞研究（英文版）》 【年(卷),期】2012(022)003

【摘要】Dear Editor,Inflammatory bowel disease(IBD),including ulcerative colitis and Crohn's disease,is generally believed to originate from the complicated interactions between genetic factors and commensal flora.This leads to the breakdown of innate immunity and the aberrant activation of the immune system,which is largely responsible for tissue damages in patients and animal models[1].A new CD4+ T cell lineage,Th17,which predominantly produces IL-17,has been revealed recently to play a key role in the development of IBD.Studies in IL-17 receptor A(IL-17RA)-knockout mice have demonstrated that IL-17 is necessary for the development of IBD.Blockade of IL-17 signaling by an IL-17RA-IgG1 fusion protein significantly attenuated IBD[2]. 【总页数】4页(607-610) 【关键词】

【作者】Zhijian Cai;Wei Zhang;Fei Yang;Lei Yu;Zhou Yu;JihHung Pan;Lie