In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular

In-vitro scolicidal activity of Mallotus

philippinensis (Lam.) Muell Arg. fruit glandular hair

extract against hydatid cyst Echinococcus

granulosus

Mayank Gangwar;Vijay C Verma;Tryambak D Singh;Sushil K Singh;RK Goel;Gopal Nath

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2013(000)008

【摘要】Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods:The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis (M. philippinensis) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus (E. granulosus), under in-vitro conditions with reference to the known standard drug Praziquantel?. Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97%and 99%respectively for 60 min treatment;while up to 93%mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100%mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract