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大剂量干扰素辅助治疗国人口腔粘膜恶性黑色素瘤的临床研究

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大剂量干扰素辅助治疗国人口腔粘膜恶性黑色素瘤的临床

研究

王润湘;吴云腾;李朝军;吕炯;郭伟;任国欣

【期刊名称】《临床肿瘤学杂志》 【年(卷),期】2014(000)004

【摘要】Objective To investigate the therapeutic effects and main side effects of high-dose interferon alpha-2b ( IFN-α-2b) adjuvant treatment in Chinese oral mucosal melanoma. Methods A total of 117 patients with oral mucosal melanomas with stageⅢ-ⅣA after surgery from May 2004 to November 2012 were analyzed retrospectively. In the 117 cases of oral mucosal melanoma, 73 cases received the adjuvant therapy of high-dose

IFN-α-2b,

of

whom

58

cases

finished

the

treatment( treatment group) and 15 cases discontinued treatment. The rest 44 cases who didn't receive high-dose IFN-α-2b adjuvant treatment were selected as the control group. The overall survival( OS) , relapse-free survival( RFS) and side effects between the two groups were compared.

Results

The

median

OS

of

117cases

was

40

months(95%CI:33-62months). For the patients with stage Ⅲ, the differences of median OS(69 months vs.65 months) and RFS(50 months vs.34 months) were not significant between the two groups. While those of cases with stageⅣA had sig-nificant differences, the median OS was 37 months vs. 20 months( P=0?028) , and the RFS was 33 months vs.

大剂量干扰素辅助治疗国人口腔粘膜恶性黑色素瘤的临床研究

大剂量干扰素辅助治疗国人口腔粘膜恶性黑色素瘤的临床研究王润湘;吴云腾;李朝军;吕炯;郭伟;任国欣【期刊名称】《临床肿瘤学杂志》【年(卷),期】2014(000)004【摘要】ObjectiveToinvestigatethetherapeuticeffectsandmainsideeffects
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