人脐带间充质干细胞对CCl4诱导肝纤维化的治疗作用研究
陈冬波;邱泽武;刘兵;吕双红;王科;王慧娜;宋亚坤;杜丽欣;罗建安;杨志岗;吴东颖;祝春青
【期刊名称】《生物技术通讯》 【年(卷),期】2013(000)003
【摘要】 目的：探讨人脐带间充质干细胞（UC-MSC）治疗肝纤维化的可行性。方法：采用CCl4腹腔注射小鼠制备肝纤维化模型，分别于第4、10周给予尾静脉注射移植UC-MSC进行治疗，检测治疗后血清学指标的改变和病理变化，观察UC-MSC对肝纤维化的疗效。结果：4周和10周进行治疗均可改善肝功能，减轻纤维化程度。结论：UC-MSC对CCl4诱导的肝纤维化具有一定的疗效。% Objective: To evaluate the use of umbilical cord-derived mesenchymal stem cells(UC-MSC) to treat chemically induced liver fibrosis. Methods: Liver fibrosis was replicated in mice via intraperitoneal injection of carbon tetrachloride(CCl4). After 4 or 10 weeks of injection, UC-MSC were transplanted into liver damaged mice via the tail vein and the treatment was evaluated by assessing serum biochemistry and histopathology. Results: In comparison with mice treated with CCl4 without UC-MSC transplantation, animals in the treatment group had signif?icantly improved serum biochemical results and exhibited a significant reduction in liver fibrosis, as evidenced by masson's trichrome staining. Conclusion: Human UC-MSC promoted recovery after liver fibrosis. 【总页数】4页(347-350)
人脐带间充质干细胞对CCl4诱导肝纤维化的治疗作用研究
