A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Tita

A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Titanium Reagent

SHI,Da-Qing(史达清);RONG,Liang-Ce(荣良策);WANG,Ju-Xian(王菊仙);ZHUANG,Qi-Ya(庄启亚);TU,Shu-Jiang(屠树江)

【期刊名称】《中国化学（英文版）》 【年(卷),期】2004(022)007

【摘要】A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCl4/Zn system. The structure was established on the basis of elemental analysis, IR, 1H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields. 【总页数】4页(743-746)

【关键词】quinazolin-4(3H)-one, low-valent titanium, o-nitrobenzamide 【作者】SHI,Da-Qing(史达清);RONG,Liang-Ce(荣良策);WANG,Ju-Xian(王菊仙);ZHUANG,Qi-Ya(庄启亚);TU,Shu-Jiang(屠树江)

【作者单位】Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China;The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou, Jiangsu 221116, China;Department of Chemistry, Xuzhou Normal University, Xuzhou,