Recent changes in the prevalence of Helicobacter pylori infection among children and adult

Recent changes in the prevalence of Helicobacter pylori infection among children and adults in high-or low-incidence regions of gastric cancer in China

ZHANG Dong-hong;ZHOU Li-ya;LIN San-ren;DING Shi-gang;HUANG Yong-hui;GU Fang;ZHANG Li;LI Yuan;CUI Rong-li;MENG Ling-mei;YAN Xiue;ZHANG Jing

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2009(122)015 【

摘

要

】

Background

The

prevalence

of

Helicobacter

pylori(H.pylon)infection varies by geographic locations.Studies indicate that the infection rate of H.pylori was previously high in China but that rates had been declining worldwide over recent decades.The aims of our study were:(1)to determine the current prevalence of H.pylori infection among children and adults residing in areas with high(Muping County,Shandong)and low(Yanqing County,Beijing)incidences of gastric cancer in China,and(2)to compare the prevalence for 2006 with the prevalence for the early 1990s.Methods Using Warthin-Starry silver staining of gastdc mucosal biopsy specimens and H.pylori stool antigen tests (HpSA),we tested a total of 2065 asymptomatic children aged 8-15 years and adults aged 40-79 years in the above two regions from May to July 2006.We evaluated 520 children and 526 adults from Muping,and 516 children and 503 adults from Yanqing.Subjects were selected randomly and H.pylon status was determined by HpSA in