熊去氧胆酸减轻移植肝缺血再灌注损伤的临床前瞻性随机
对照研究
王书云;唐华美;彭志海;裘国强;陈国庆;徐军明;钟林
【期刊名称】《中华器官移植杂志》 【年(卷),期】2008(029)003
【摘要】Objective To investigate the effects of ursodeoxycholic acid(UDCA)alleviating
ischemia/reperfusion
injury(IRI)in
liver
transplantation. Methods Eighty adult patients with endstage liver diseases were randomly divided into two groups:UIXTA group(n=42)in which UDCA 38)in which UDCA was not administered.The two groups were statistically compared in liver biochemical parameters,rate of severe
IRI-induced
graft
dysfunction,acute
cellular
rejection(ACR)episodes,drug-induced hepatotoxicity,viral hepatitis and recurrence of primary liver disease within posttransplant 3 weeks as well as rate of vascular,biliary complications and death within post-transplant 3 months.Results Warm ischemia time(WIT)and cold ischemia time(CIT)in
UDCA
group
were
respectively(3.33±0.92)min
and(10.3±1.9)h,and those in control group were(3.68±1.16)min and(9.8±2.4)h.There were no significant differences in these two parameters between the two groups.In UDCA group,serum ALT levels on post-transplant day 7,14,21 were significantly lower than those in control group(P＜0.05),and compared with control group,serum levels
熊去氧胆酸减轻移植肝缺血再灌注损伤的临床前瞻性随机对照研究
