调节性T细胞在慢性粒细胞白血病中的表达及临床意义
周莉;徐运孝
【期刊名称】《中国肿瘤临床》 【年(卷),期】2012(039)009
【摘要】Objective: To evaluated the proportion of CD4+CD25+ Tregs cells in the peripheral blood of patients with chronic my-elogenous leukemia ( CML ), and to investigate the correlation among the proportion of CD4+CD25+Tregs, curative effect, and prognosis of patients with CML at different phases. The onset and turnover of CML based on immunology were discussed. Methods: Flow cy-tometry was used to determine the proportion of CD4+CD25+ Tregs in peripheral blood from 23 CML patients and 10 normal controls. The proportion was compared among CML patients, normal controls, and different phases of the disease. The correlation between the proportion of T cells and clinical parameters was analyzed. Results: Compared with normal controls, the percentage of CD4+CD25+ Tregs in the peripheral blood mononuclear cells ( PBMC ) was significantly lower ( P < 0.05 ) in patients who underwent initial treatment of CML and in those with accelerated or blastic phase CML. Moreover, there were no significant differences in the percentage of CD4+CD25+ Treg cells in the PBMC of patients during treatment of CML and normal controls ( P > 0.05 ). Percentages of CD4+T cells in the PBMC of patients receiving initial
调节性T细胞在慢性粒细胞白血病中的表达及临床意义
