好文档 - 专业文书写作范文服务资料分享网站

益生菌联合化痰消瘀汤治疗慢性萎缩性胃炎疗效及对脂质过氧化损伤

天下 分享 时间: 加入收藏 我要投稿 点赞

益生菌联合化痰消瘀汤治疗慢性萎缩性胃炎疗效及对脂质

过氧化损伤指标的影响

吕涛;刘皓;魏睦新

【期刊名称】《现代中西医结合杂志》 【年(卷),期】2017(026)021

【摘要】Objective It is to observe the curative effect of probiotics combined with Huatanxiaoyu decoction in chronic atrophic gastritis (CAG) and its influence on lipid peroxidation injury indicators. Methods 90 cases of patients with CAG were randomly divided into 2 groups, the control group was given Weifuchun Tablets; the treatment group was given probiotics combined with Huatanxiaoyu decoction. All patients were treated for 3 months. The clinical curative effect was analyzed, the clinical symptom scores, pathology scores of gastric mucosa, the levels of SOD, MDA and GSH-Px in gastric mucosa pre-post treatment were observed in the two groups, the adverse reactions were recorded in the two groups during treatment. Results The total effective rate was 95.56% in treatment group and 77.78% in control group, there was significant difference (P<0.05). After treatment, the clinical symptom scores and the scores of inflammation of the mucosa, inflammation activity, reducing of gland were increased significantly in the two groups (all P<0.05), and these scores of the treatment group were significantly higher than the control group (all P<0.05); the levels of SOD, MDA and

GSH-Px were significantly improved than before treatment in the two groups (all P<0.05), and the improvements of these indicators in the treatment group were significantly better than the control group (all P<0.05). There was no obvious adverse reactions in the two groups. Conclusion The probiotics combined with Huatanxiaoyu decoction can effectively improve the clinical symptoms of CAG patients, it can regulate resist the free radical impairment of gastric mucosa.%目的 观察益生菌联合化痰消瘀汤治疗慢性萎缩性胃炎(CAG)的疗效及对脂质过氧化损伤指标的影响,探讨其作用机制.方法 将90例慢性萎缩性胃炎患者随机平均分为2组,对照组给予胃复春片口服治疗,观察组给予益生菌联合化痰消瘀汤口服治疗,2组疗程均为3个月.统计2组临床疗效,观察2组治疗前后中医证候积分、胃黏膜组织病理评分及胃黏膜组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)活性变化情况,记录2组在治疗过程中出现的不良反应.结果 观察组总有效率为95.56%,对照组为77.78%,2组比较差异有统计学意义(P<0.05);疗程结束后,2组各项中医证候积分及黏膜炎症、炎症活动度、腺体数量评分均明显低于治疗前(P均<0.05),且观察组上述各项评分均明显低于对照组(P均<0.05);2组胃黏膜组织中SOD、GSH-Px活性均明显高于治疗前(P均<0.05),MDA水平均明显低于治疗前(P均<0.05),且观察组上述指标改善情况均明显优于对照组(P均<0.05).2组均无明显不良反应发生.结论 益生菌联合化痰消瘀汤可以有效改善慢性萎缩性胃炎患者的临床症状以及胃黏膜病变,二者可能是通过抗脂质过氧化损伤而起保护和修复胃黏膜作用. 【总页数】4页(2281-2283,2297)

【关键词】益生菌;化痰消瘀汤;慢性萎缩性胃炎;脂质过氧化损伤 【作者】吕涛;刘皓;魏睦新

【作者单位】南京医科大学第一附属医院,江苏 南京 210029;南京医科大学第一附属医院,江苏 南京 210029;南京医科大学第一附属医院,江苏 南京 210029 【正文语种】中文 【中图分类】R573.32 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_modern-journal-integrated-traditional-chinese-western-medicine_thesis/0201218556033.html 【相关文献】

1.半夏厚朴汤加味对慢性萎缩性胃炎大鼠胃黏膜血流量及脂质过氧化损伤的影响研究 [J], 李宁宁; 郭海; 雷延飞

2.润燥化痰消瘀方加减治疗慢性萎缩性胃炎疗效观察 [J], 蔡巍巍; 王婷; 魏睦新 3.化痰消瘀方治疗慢性萎缩性胃炎伴胆汁反流的临床疗效及对胃肠激素和炎症、氧化应激相关因子水平的影响 [J], 刘皓; 吕涛; 王岚; 魏睦新

4.益生菌联合序贯疗法治疗幽门螺杆菌相关性慢性萎缩性胃炎96例的疗效分析 [J], 谢丽华; 胡红松; 谭朝晖; 陈晓红; 黄雪梅; 陈学福

5.胃复春联合益生菌治疗幽门螺杆菌感染的慢性萎缩性胃炎疗效分析 [J], 杨林青; 窦逾常; 李霞; 逯遥

以上内容为文献基本信息,获取文献全文请下载

益生菌联合化痰消瘀汤治疗慢性萎缩性胃炎疗效及对脂质过氧化损伤

益生菌联合化痰消瘀汤治疗慢性萎缩性胃炎疗效及对脂质过氧化损伤指标的影响吕涛;刘皓;魏睦新【期刊名称】《现代中西医结合杂志》【年(卷),期】2017(026)021【摘要】ObjectiveItistoobservethecurativeeffectofprobioticscomb
推荐度:
点击下载文档文档为doc格式
95ry88e9uw4x67j2pwjr92i2p9mf5d01dmz
领取福利

微信扫码领取福利

微信扫码分享