Product Data Sheet
Recombinant Mouse Interleukin-6, His (CHO-expressed)
Cat. No.:Synonyms:Species:Source:Accession:Gene ID:Molecular Weight:
HY-P7378rMuIL-6, His; B cell differentiation factor; IL6MouseCHOP085051619324-26 kDa
Inhibitors?Agonists?Screening LibrariesPROPERTIES
AA Sequence
FPTSQVRRGDMRKELCNGNSNQEICLLKISDTETLIHIFNLRTKTIQFIL
FTEDTTPNRPDCMNNDDALASGLLEYHSYLQEVKDLHKIVKSLEEFLKVT
VYTTSQVGGLENNLKLPEIQEYMKNNLKDNLPTPISNALLLRSTRQTHHH
ITHVLWEIVERNDGCYQTGYKKDKARVLQRTDKLESQKEWHHH
Biological ActivityAppearanceFormulationEndotoxin LevelReconsititution
The ED50 is <3 pg/mL as measured by 7TD1 cells.Lyophilized powder.
Lyophilized after extensive dialysis against PBS.<0.2 EU/μg, determined by LAL method.
Reconstitute the lyophilized recombinant Mouse Interleukin-6, His (CHO-expressed) (rMuIL-6, His) to 100 μg/mL using ddH2O or diluted with PBS.
Storage & StabilityLyophilized recombinant Mouse Interleukin-6, His (CHO-expressed) (rMuIL-6, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
ShippingRoom temperature in continental US; may vary elsewhere.
DESCRIPTION
Background
Interleukin-6 (IL-6) is one of the most important mediators of the acute phase reaction in liver[1]. Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. IL-6 promotes specific differentiation of na?ve CD4+ T cells, thus performing an important function in the linking of innate to acquired
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immune response. IL-6, in combination with transforming growth factor (TGF)-β, is indispensable for Th17 differentiation from na?ve CD4+ T cells, but that IL-6 also inhibits TGF-β-induced Treg differentiation[1].
REFERENCES
[1].?Frorath B, et al. Production of recombinant rat interleukin-6 in Escherichia coli using a novel highly efficient expression vector pGEX-3T.[2].?Tanaka T, et al. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014 Sep 4;6(10):a016295.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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重组小鼠白细胞介素- 6, His（CHO 表达）作用机制- Medchemexpress- MCE中国
