Enlarged tongue due to primary systemic amyloidosis：clinicopathologic observation

Enlarged tongue due to primary systemic amyloidosis：clinicopathologic observation

潘卫红;李娜萍;梁国芬

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2004(000)011

【摘要】@@Primary amyloidosis (AL) is characterized by deposition of abnormal extra cellular protein in the form of fibrils in many organs, especially the heart, kidneys, gastrointestinal tract, and peripheral nervous system.1 Involvement of the tongue is not uncommon in primary AL. In 22 % to 26 % of patients suffering from AL, amyloid deposition in the tongue can result in an enlarged tongue.2 Lingual changes arising from localization or from all over, AL has been reported frequently as initial signs of the disease. Macroscopically, it is difficult to distinguish AL of the tongue from other lesions. In view of the variety of protein species involved and the wide spectrum of possible clinical presentations,3 the diagnosis of lingual AL is frequently overlooked, because immunohistochemical studies of such cases have not been undertaken. Here we describe two male patients with primary systemic AL who developed enlarged tongues. In addition to the manifestation of lingual AL, in which oral signs were the primary indicators of the disease, we describe the immunohistochemical findings of the tongue to discuss diagnostic criteria for lingual amyloid in primary AL.

【总页数】3页(1758-1760)

【关键词】amyloidosis;tongue;pathology 【作者】潘卫红;李娜萍;梁国芬

【作者单位】Department of Stomatology, Union Hospital, Huazhong University

of

Science

and

Technology,

Wuhan

430022,

China;Department of Pathology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Cardiovascular Medicine, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-journal_thesis/0201254952307.html 【相关文献】

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