多囊卵巢综合征患者核糖体蛋白基因S 26与内分泌激素水
平相关性研究
季新梅;梁秀文;马娟
【期刊名称】《中国计划生育和妇产科》 【年(卷),期】2018(010)004
【摘要】Objective To analyze the relationship between different kinds of ribosomal protein gene 26(RPS26) and indexes in polycystic ovarian syndrome(PCOS) patients. Methods Selected 100 PCOS patients who were diagnosed in Shenzhen Longhua District People's Hospital from June 2015 to June 2016. Gene RPS26 was tested. Compared the differences
among
age,
body
mass
index(BMI),anti-Müllerian
luteinizing
sex
hormone(AMH), hormone(LH),
follicle stimulating hormone(FSH),
prolactin(PRL), estradiol(E2), testosterone(T),
hormone-binding globulin(SHBG) and free androgen index(FAI). Pearson Test was carried between the indexes and rs56696262. Results There
were
three
types
of
rs56696262,A/A(4/100),A/T(31/100),T/T(65/100). But in the study,the patients with A/A gene were too few to analyze. Between A/T and T/T, there
were
no
significant
differences
among
age,AMH,FSH,LH,PRL,E2and SHBG. There were significant differences among BMI, T and FAI. Pearson test showed that three indexes,BMI,T,FAI were relevant with rs56696262. Conclusion In this study,it was found
that the A / T and T / T genotypes of rs 56696262 were not significantly correlated with age,AMH, FSH, LH, PRL, E2and SHBG. There was a correlation between BMI,T,FAI and rs 56696262 in A / T group and T / T group.%目的 探讨多囊卵巢综合征(polycystic ovarian syndrome, PCOS)患者核糖体蛋白基因 S 26 (ribosomal protein gene S 26,RPS 26)不同基因型的内分泌激素指标之间是否存在相关性.方法 选取2015年7月至2016年3月在深圳市龙华区人民医院就诊的 PCOS 患者100例,进行基因测序 RPS 26的 rs 56696262基因型,对比不同基因型的年龄、体质量指数(body mass index,BMI)、抗苗勒氏管激素(anti -Müllerian hormone,AMH)、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone, LH)、催乳素(prolactin,PRL)、雌二醇(estradiol,E2)、睾酮(testosterone,T)、性激素结合球蛋白(sex hormone-binding globulin,SHBG)、游离雄激素指标(free androgen index, FAI),再将rs 56696262位点的3种基因型与以上指标进行相关性分析.结果 rs 56696262
位点共有
3
种基因
型,A/A(4/100),A/T(31/100),T/T(65/100),因为A/A的病例数太少,无法进行数据分析.对A/T和T/T两组病例的研究中得出BMI、T和FAI差异有统计学意义(P<0.05),存在相关性;但年龄、AMH、FSH、LH、PRL、E2、SHBG比较差异无统计学意义(P>0.05),不存在相关性.结论 本研究未发现rs 56696262位点的A/T和T/T基因型与年龄、AMH、FSH、LH、PRL、E2、SHBG存在明显相关性,而A/T组和T/T组的BMI、T、FAI与rs 56696262位点存在相关性. 【总页数】4页(49-52)
【关键词】核糖体蛋白基因S26;多囊卵巢综合征;相关性分析
【作者】季新梅;梁秀文;马娟
【作者单位】518109 广东 深圳,深圳市龙华区人民医院妇科;518109 广东 深圳,深圳市龙华区人民医院妇科;518109 广东 深圳,深圳市龙华区人民医院妇科 【正文语种】中文 【中图分类】R711.75 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-family-planning-gynecotokology_thesis/0201215186255.html 【相关文献】
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多囊卵巢综合征患者核糖体蛋白基因S 26与内分泌激素水平相关性研究
