Roles of TGF-β family signaling in stem cell renewal
and differentiation
Tetsuro Watabe;Kohei Miyazono
【期刊名称】《细胞研究（英文版）》 【年(卷),期】2009(019)001
【摘要】Transforming growth factor(TGF)-βs and their family members,including bone morphogenetic proteins(BMPs),Nodal and acfivins.have been implicated in the development and maintenance of various organs,in which stem cells play important roles.Stem cells are characterized by their ability to seif-renew and to generate differentiated cells of a particular tissue.and are classifed into embryonic and somatic stem cells.Embryonic stem(ES)cells self-renew indefinitely and contribute to derivafives of all three primary germ layers.in contrast,somatic stem cells,which can be identified in various adult organs.exhibit Iimited abilities for self-renewal and differentiation in most cases.The multi-lineage differentiation capacity of ES cells and somatic stem cells has opened possibilities for cell replacement therapies for genetic.malignant and degenerative diseases.In order to utilize stem cells for therapeutic applications,it is essential to understand the extrinsic and intrinsic factors regulating self-renewal and differentiation of stem cells.More recently,induced pluripotent stem(iPS)cells have been generated from mouse and human fibroblasts
that re-semble ES cells via ectopic expression of four transcription factors.iPS cells may have an advantage in regenerative medicine,since they overcome the immunogenicity and ethical controversy of ES cells.Moreover,recent studies have highlighted the involvement of cancer stem cells during the formation and progression of various types of
cancers,including
leukemia,glioma,and
breast
cancer.Here,we
illustrate the roles of TGF-β family members in the mainte-nance and differentiation of ES cells,somatic stem cells,and cancer stem cells. 【总页数】13页(103-115) 【关键词】
【作者】Tetsuro Watabe;Kohei Miyazono
【作者单位】Department of Molecular Pathology,Graduate School of Medicine,The University of Tokyo,7-3-1 Hongo,Bunkyo-ku,Tokyo 113-0033,Japan;Department of Molecular Pathology,Graduate School of Medicine,The University of Tokyo,7-3-1 Hongo,Bunkyo-ku,Tokyo 113-0033,Japan 【正文语种】中文 【中图分类】Q2 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_cell-research-english_thesis/0201255252185.html 【相关文献】
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Roles of TGF-β family signaling in stem cell renewal and differentiation
