CMYK
中国神经精神疾病杂志
2020年第46卷第5期
263
．论著．
帕金森病合并H间嗜睡患者临床特征及相关因
素分析
＊
李伟．
肖卫民
＊
符小丽
＊
卢志豪
＊
钟伙花
＊
陈仰昆心
【摘要】目的分析合并H间嗜睡(excessivedaytime sleepiness, EDS)
帕金森病患者临床特征并探讨其影响因素。方法本研究共纳入100例帕金森病患者。根据Epworth嗜睡最表，将其分为H间嗜睡组(EDS组，Epworth嗜睡歌表评分>10分，36例）和无日间嗜睡组（无EDS组，Epworth嗜睡量表评分<10分，64例）。所有患者均进行帕金森病综合评分量表
(UPDRS)评分及Hoehn-Y ahr(H-Y)评定，并对其运动功能、抑郁及认知功能、日常生活能力进行评估，运用logistic回归寻找EDS的相关因素。结果帕金森病患者中EDS发生比率为36%(36/100)。EDS组的MMSE评分及H常生活能力较尤EDS组低，抗抑郁药使用率及左旋多巴剂扯较尤EDS组高(P值均＜0.05)。相关分析显示，Epworth嗜睡量表评分与MMSESchwab和英格兰日常生活活动量表得分呈显著负相关，与UPDRSIL UPDRSIII及H-Y分级呈显著正相关。多因素logistic回归分析显示，男性(0R=4.038,95%CI: 1.486~ 12.906, P=0.001)及MMSE(OR=0.847,95%CI: 0.759~0.945, P=0.003)为EDS的显著相关因素。结论帕金森病患者合并EDS较常见，伴有EDS的帕金森病患者日常生活能力明显下降。男性及认知功能下降与EDS密切相关。
【关键词】帕金森病日间嗜睡Epworth嗜睡措表日常生活能力
【中图分类号】R742.5
【文献标识码】A
An analysis of clinical characteristics and related factors in Parkinson disease patients with excessive daytime sleepiness. LI Wei, XIAO Weimin, FU Xianli, LU Zhih叩，ZHONGHuohua, CHEN Y叩gkun.Dep叩mentof Neurology, Donggu叩People'sHospital,, South N0.3 W叩如Ro叫，Dongguan,523000, Guangdong Province, China. Tel: 0769-28636812.
【Abstract】ObjectiveTo analyze the clinical characteristics of Parkinson disease (PD) patients with excessive daytime sleepiness (EDS) and to explore the influencing factors. Methods A total of 100 PD patients were eligible and enrolled in the study. By the Epworth sleepiness scale (ESS), patients were divided into the EDS group (ESS;;:; lO)with 36 patients and the non-EDS group (ESS actors of EDS. Conclusion EDS is common in Parkinson disease patients and the ability of daily living is significantly reduced in Parkinson disease with EDS. Male and doi: 10.3969/j.issn.1002-0152.2020.05.002 ＊ 广东省科技计划项目（编号：2017A020215002)＊ 。 广东省东莞市人民医院神经内科（东莞523000) 通信作者(E-mail:cykun78@163.com) —]
帕金森病合并日间嗜睡患者临床特征及相关因素分析 - 图文
