幽门螺杆菌L型和HPV16、18感染在人食管癌中同步检
测的对比分析
于东红;王萍;姚敏;万敏
【期刊名称】《中国人兽共患病学报》 【年(卷),期】2000(016)006
【摘要】目的研究幽门螺杆菌L型(Hp-L型)和HPV16、18感染与人食管癌的关系，探讨Hp-L型致癌机制。方法应用革兰染色和免疫组化染色技术，对112例食管鳞癌和30例对照组进行Hp-L型和HPV16、18同步检测。结果革兰染色L型检出率(67.9％)与对照组(26.7％)有显著性差异(P＜0.05)；与免疫组化Hp-L型抗原检出阳性率(65.2％)无显著性差异(P＞0.05)。Hp-L型检出阳性事为61.6％(69／112)。HPV16、18表达阳性率为69.6％，与Hp-L型检出阳性率无显著性差异(P＞0.05)；Hp-L型和HPV16、18同时阳性者占59.8％(67／112)结论 Hp-L型和HPV16、18感染与食管癌发生相关。Hp-L型感染可能是食管癌除病毒之外的又一生物性致癌因素。%To study the association of Helicobacter pylori L-form(Hp-L) infection and HPV16、18 infection and human esophageal carcinoma (EC). To study the role of Hp-L in EC. Methods : Gram's staining and immunohistochemical techniques was used to detect the Hp-L in fection and the expression of HPV16、18 protein in 112 cases of EC with 30 normal esophageal squamous epithelial. Results The positivity rate of the infection of bacterial L-form(67. 9％ )in cancer group were significantly higher than that in normal group(26. 7％)with Gram's staining (P＜0. 05). The antigen of
幽门螺杆菌L型和HPV16、18感染在人食管癌中同步检测的对比分析
