硼替佐米治疗以肾功能不全为首发症状的多发性骨髓瘤的
研究
辜学忠;闻艳;姚翔媚;陆智祥;虞利群;史克倩
【期刊名称】《中国社区医师》 【年(卷),期】2016(032)032
【摘要】目的：探讨以肾功能不全为首发症状的多发性骨髓瘤采用硼替佐米治疗的临床疗效。方法：以肾功能不全为首发症状的初治多发性骨髓瘤患者20例，平分成两组，对研究组给予 BDT 方案治疗(硼替佐米+地塞米松+沙利度胺)，对照组给予 CDT 方案治疗(环磷酰胺+地塞米松+沙利度胺)，观察两组治疗效果。结果：两组 CR、PR、SD、PD 和 OR 差异有统计学意义(P＜0.05)。结论：硼替佐米方案治疗以肾功能不全为首发症状的多发性骨髓瘤效果显著，可明显改善肾功能，安全、可靠，可作为靶向性治疗药物。%Objective:To investigate the clinical curative effect of bortezomib in the treatment of multiple myeloma patients with renal dysfunction as initial symptom.Methods:20 multiple myeloma patients with renal dysfunction as initial symptom for initial treatment were selected.They were randomly divided into the two groups on average.The study group was treated with BDT scheme(bortezomib and dexamethasone and thalidomide).The
control
group
was
treated
with
CDT
regimen(cyclophosphamide and dexamethasone and thalidomide).We observed the therapeutic effect of the two groups.Results: The difference on CR,PR,SD,PD and OR between groups was statistically
硼替佐米治疗以肾功能不全为首发症状的多发性骨髓瘤的研究
