Antinociceptive and anti-inflammatory activities of crude extracts of Ipomoea involucrata

Antinociceptive and anti-inflammatory activities of crude extracts of Ipomoea involucrata leaves in

mice and rats

Uche Fidelia Ijeoma;Shorinwa Olusayo Aderonke;Okorie Ogbonna;Mgbahurike Amaka Augustina;Chijioke-Nwauche Ifeyinwa

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2011(000)002

【摘要】Objective: To investigate antinociceptive and anti-inflammatory activities of crude extract from Ipomoea involucrata leaves (Convolvulaceae) in mice and rats.Methods:The antinociceptive activity was tested using acetic acid-induced abdominal writhing test in mice. The anti-inflammatory activity was evaluated using egg albumin–induced oedema of rat paw.Results:Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, terpenoids and tannin. At the doses of 25-100 mg/kg,Ipomoea involucrata exhibited dose-dependent and significant increase in pain threshold in acetic acid–induced writhing test of mice (P<0.05, student t-test) The administration ofIpomoea involucrata leaf extract (25-100 mg/kg) showed dose-dependent decreases in paw volume of egg albumin induced oedema in rats and a significant higher anti-inflammatory activity compared to the standard control (Aspirin). Conclusions: These results support the claims on the traditional use of the ofIpomoea involucrata leaves in the