MicroRNA-31在上皮性卵巢癌中的表达及其与预后的关
系
徐志宏;吴小华;姚铁柱;梁秀琴
【期刊名称】《中国现代医学杂志》 【年(卷),期】2024(028)004
【摘要】目的 本研究旨在探讨microRNA-31(miR-31)在上皮性卵巢癌(EOC)中的表达水平与临床病理学因素以及预后的关系.方法 采用实时荧光定量聚合酶链反应(qRT-PCR)检测150例EOC患者组织中miR-31的表达水平,将miR-31表达情况与随访结果和临床资料相结合进行统计学分析.结果 在EOC组织中miR-31的表达较癌旁正常卵巢组织降低(P<0.05).miR-31的低表达与较差的组织学分级、较多的淋巴结转移、更广泛的腹膜转移和更晚期的病理分期有关(P<0.05),而与其他临床病理学因素无关(P>0.05).此外,miR-31的表达是患者总生存的独立预测因子.结论 miR-31可能是EOC一个新的诊断和预后标志物.%Objective To investigate the expression of miR-31 in epithelial ovarian cancer (EOC), and analyze the relationship of its expression with clinicopathological features and prognosis. Methods qRT-PCR was performed to detect miR-31 expression in the EOC tissues. The correlations of miR-31 expression with follow-up results and clinicopathological factors of the EOC patients were analyzed. Results The expression of miR-31 in the EOC tissues was reduced significantly compared with the adjacent normal tissues (P < 0.05). Low expression of miR-31 was correlated with higher histological grade, lymph node
MicroRNA-31在上皮性卵巢癌中的表达及其与预后的关系
