ACS患者不同Hcy、MAPK水平与病情严重程度的关系探
讨
金鹏;周琪;张敏莉
【期刊名称】《中西医结合心脑血管病杂志》 【年(卷),期】2015(000)004
【摘要】Objective To investigate the relationship between the levels of homocysteine(Hcy)and mitogen activated protein kinases (MAPK)and severity
of
disease
in
patients
with
acute
coronary
syndrome(ACS).Methods Two hundreds and eight patients with ACS were measured with levels of MAPK and Hcy by ELISA.The patients were divided into two groups:Group A [non homocys-teine (NHhcy)group,n= 106]and group B [homocysteine(Hhcy)group,n= 102].The coronary lesion count was assessed accord-ing to CAG.One month after the onset,cardiac ultrasound measurement applications was used to evaluate heart ejection fraction (LVEF).Results The proportion of single vessel lesion in group A was higher than that in group B(P<0.01).The proportion of double and three vessel lesion in group B was higher than that in group A(P<0.01).The concentration of MAPK in group B was higher than that in group A(P<0.05).The LVEF in group B was lower than that in group A(P<0.05).Conclusion Hcy can be as a predictor of disease severity in patients with ACS.MAPK can be as a supplement of prognosis evaluation in ACS patients by the appli-cation of Hcy.%目的：探讨急性冠
脉综合征(ACS)患者不同同型半胱氨酸(Hcy)和丝裂原活化蛋白激酶(MAPK)水平与病情严重程度的关系。方法将208例 ACS患者采用 ELISA 法分别测定其外周血 Hcy和 MAPK水平,根据其值分为非高同型半胱氨酸(A组,106例)及高同型半胱氨酸(B组,102例)；冠状动脉病变支数根据冠状动脉造影结果评定。发病1个月后应用心脏超声测定心脏射血分数(LVEF)。结果 A组单支血管病变比例显著高于B组(P<0.01),B组双支血管病变及三支血管病变比例显著高于 A组(P<0.01)。B组 MAPK浓度较 A组明显升高(P<0.05),LVEF较 A组明显降低(P<0.01)。结论同型半胱氨酸可作为 ACS患者病情严重程度的预测指标。而 MAPK可作为 ACS患者在应用同型半胱氨酸评价预后的补充。 【总页数】3页(536-538)
【关键词】急性冠脉综合征;同型半胱氨酸;丝裂原活化蛋白激酶 【作者】金鹏;周琪;张敏莉
【作者单位】中国石油天然气集团公司中心医院 河北廊坊 065000;中国石油天然气集团公司中心医院 河北廊坊 065000;中国石油天然气集团公司中心医院 河北廊坊 065000 【正文语种】中文
【中图分类】R541.4;R256.2 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-integrative-medicine-cardio-cerebrovascular-disease_thesis/0201232830440.html 【相关文献】
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ACS患者不同Hcy、MAPK水平与病情严重程度的关系探讨
