来曲唑与克罗米芬对多囊卵巢综合征妇女促排卵及生殖激
素变化的影响
李红真;乔杰
【期刊名称】《中国临床药理学杂志》 【年(卷),期】2012(028)007
【摘要】Objective To compare the clinical effects and endocrino-logical environment between letrozole and clomiphene citrate ( CC) stimulated cycles in women with polycystic ovarian syndrome ( P-COS). Methods A prospective, case - control study was conducted. Infertile women with PCOS were given letrozole 2. 5 mg per day or CC 50 mg per day for five days. Timed intercourse or intrauterine insemination (IUI) was performed on the day of follicles rupture. Results Both ovulation rate and pregnancy rate were not different between two groups. Letrozole group had less mature follicles. Thicker endoraetriums and lower E2 levels were seen in the letrozole group. Androstenedione was significantly higher in the letrozole group on the cycle day 8. Conclusion Letrozole is effective in ovulation stimulation. It might be helpful in reduction of multiple pregnancy. The change of androgen induced by letrozole might adversely influence the pregnancy rate in women with PCOS.%目的 比较用来曲唑和克罗米芬治疗多囊卵巢综合征(PCOS)患者的促排卵效果和生殖激素的变化.方法 用前瞻性、病例对照研究,PCOS不孕症患者口服来曲唑每日2.5mg或克罗米芬每日50mg,共5d.排卵日同房或行宫腔内人工
授精.结果 来曲唑组和克罗米芬组的排卵率和妊娠率无明显差异.来曲唑组的成熟卵泡数显著少于克罗米芬组,子宫内膜厚度较大于克罗米芬组；但雌激素水平低于克罗米芬组.月经周期第8d,来曲唑组的雄烯二酮水平显著高于克罗米芬组.结论 来曲唑用于促排卵有效,且可能有助于减少多胎妊娠的发生；但来曲唑所诱导的雄激素变化,可能对子宫内膜产生不利影响,从而影响了PCOS患者的妊娠率.
【总页数】3页(502-504)
【关键词】来曲唑;多囊卵巢综合征;促排卵;克罗米芬 【作者】李红真;乔杰
【作者单位】北京大学第三医院生殖医学中心,北京100191;北京大学第三医院生殖医学中心,北京100191 【正文语种】中文
【中图分类】R979.23;R711.75 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-clinical-pharmacology_thesis/0201241837047.html 【相关文献】
1.来曲唑联合克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响 [J], 徐静波; 万化玉
2.来曲唑与克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响 [J], 尹锦芳; 段丽莎
3.来曲唑与克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响 [J],
王玉
4.来曲唑与克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响 [J], 田颖; 许歆; 赵霞; 孟凡婷; 赵晓晶
5.来曲唑、克罗米芬影响多囊卵巢综合征患者促排卵、生殖激素变化的情况观察 [J], 穆琳
以上内容为文献基本信息，获取文献全文请下载
来曲唑与克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响
