Alendronate阻止牙槽骨骨吸收的实验研究
王晓敏;杨宗萍;于世凤
【期刊名称】《现代口腔医学杂志》 【年(卷),期】2001(015)002
【摘要】Objective．Osteoporosis and periodontal disease animal models were used to evaluate the anti-resorption effect of alendr onate on bone.Methods．To establish osteoporosis and alveo lar bone resorption animal models.The experimental groups (ovariectomized dental ligature group and simple dental ligature group) were given alendronate in 0. 5mg/kg BW by subcutaneous injection after six weeks of ovariectomy and dental ligature,three times a week for 6 weeks.All the animals were sacrifised 12 weeks after the operation.The blood samples were collected for determination of bioch emical indexes.The left femora and jaw bone were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics.Results．As compared with the control groups (without alendronate),the values of experimental groups (with alendronate ) were all significantly improved on bone density and bone anti-curve power.The alkaline phosphatase,calcium in serum of ovariectomy groups (without alendronate ) were obviously increased.In the alendronate group,however,these indexes werec lose to normal levels.In histomorphometry,there were little inflammation in gingiva and
Alendronate阻止牙槽骨骨吸收的实验研究
