CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal

CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal

transplant recipients

WANG Yu-yuan;ZHANG Ming;LU Fu-ming;JIAO Zheng;QIU Xiao-yan

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2012(125)023

【摘要】Background Cyclosporin A (CsA) is a substrate of both cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp),some of the single nucleotide polymorphisms (SNPs) in these genes are associated with interindividual variations in CsA pharmacokinetics.We studied the influence of these SNPs on the incidence of rejection and CsA nephrotoxicity,as well as pneumonia within one year after renal transplant and post-transplantation diabetes mellitus (PTDM),in order to find whether genetic evaluation may help to identify patients at risk and to

modulate

CsA

therapy

to

optimize

graft

and

patient

outcomes.Methods A total of 208 renal transplant recipients receiving CsA

were

genotyped

for

ABCB1

by

(C1236T,G2677T/A,and direct

sequencing

C3435T),CYP3A4*1G,and CYP3A5*3

method.Retrospective case control study was utilized to identify the association

between

CYP3A4*1G,CYP3A5*3,ABCB1

genetic

polymorphisms and CsA-related outcomes.Results The patients with a CYP3A4*1G/*1G genotype were found to have a higher incidence of