糖原合成酶激酶-3参与神经保护的研究进展
文国强;刘涛
【期刊名称】《中国临床神经科学》 【年(卷),期】2015(000)001
【摘要】糖原合成酶激酶-3(GSK-3)是一种丝氨酸／苏氨酸蛋白激酶，有两种亚型，即GSK-3α和GSK-3β。GSK-3的活性受磷酸化和非磷酸化机制调节，可以磷酸化多种蛋白质，参与细胞分化、凋亡等多种生理过程的调节。GSK-3与脑缺血、阿尔茨海默病及其他神经精神疾病的发生都有关。%Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase, with two distinct forms termed GSK-3αand GSK-3β. Its activation is regulated by both phosphorylation and nonphosphorylation mechanisms. GSK-3 is implicated in the regulation of many physiological responses in mammalian cells by phosphorylating substrates. GSK-3 has been found involved in various neurologic diseases such as cerebral ischemia, Alzheimer’s disease. 【总页数】6页(82-87)
【关键词】糖原合成酶激酶-3;神经保护;脑缺血;阿尔茨海默病 【作者】文国强;刘涛
【作者单位】海南省人民医院神经内科570311;海南省人民医院神经内科570311
【正文语种】中文 【中图分类】R749.1
糖原合成酶激酶-3参与神经保护的研究进展
