METHOD FOR THE PURIFICATIOIN OF INTACT, CORRECTLY-FOLDED INSULIN-LIKE GROWTH FACTOR-1

METHOD FOR THE PURIFICATIOIN OF INTACT, CORRECTLY-FOLDED INSULIN-LIKE GROWTH

FACTOR-1

申请(专利)号： EP19920904088

专利号： EP0567554A1 主分类号： C07K1/14

申请权利人： THE SALK

INSTITUTE

BIOTECHNOLOGY INDUSTRIAL ASSOCIATES, INC. 公开国代码： EP 优先权国家： US

申请日： 1992-01-15 公开公告日： 1993-11-03

分类号： C07K1/14

发明设计人： BRIERLEY,

RUSSELL, A.;

HOLTZ, GREGORY, C.

申请国代码： EP

优先权： 19910116 US

19910641430; 19911028 US 19910785171

摘 要 附 图：

摘 要：

Describes a process of purification and recovery of peptide growth factor-1 analogue of insulin (IGF-1) in an intact form, and properly folded monomer, from large volumes of a medium containing IGF-1. This method consists in performing a series of adsorption desorption steps by means of a combination of adsorbents cation exchange and hydrophobic

interaction. The IGF-1 peptide product is highly purified and suitable for a variety of clinical applications. 主权项：

1. Method for the purification of monomeric, intact, correctly-folded insulin-like growth factor-1 p

权 利 要 求 说 明 书

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