Product Data?Sheet
Acivicin
Cat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:
HY-W01658642228-92-2C?H?ClN?O?178.57ParasiteAnti-infectionPowderIn solvent
-20°C-80°C-20°C
3 years6 months1 month
Inhibitors?Agonists?Screening LibrariesBIOLOGICAL ACTIVITY
?物活性
Acivicin (AT-125) 是?种由猪链霉菌产?的天然产物，是 γ-?氨酰转肽酶 (GGT) 抑制剂。Acivicin 可以跨越?脑屏障，并具有抗癌，抗寄??的特性。
IC?? & Target
GGT[1]
REFERENCES
[1].?Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition?Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26.
[2].?Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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