Age and sex differences in microRNAs expression during the process of thymus aging

Age and sex differences in microRNAs expression

during the process of thymus aging

Dongguang Guo;Yaqiong Ye;Junjie Qi;Xiaotong Tan;Yuan Zhang;Yongjiang Ma;Yugu Li

【期刊名称】《生物化学与生物物理学报：英文版》 【年(卷),期】2017(049)005

【摘要】The gender-biased thymus involution and the importance of microRNAs (miRNAs,miRs) expression in modulating the thymus development have been reported in many studies.However,how males and females differ in so many ways in thymus involution remains unclear.To address this question,we investigated the miRNA expression profiles in both untreated 3-and 12-month-old female and male mice thymuses.The results showed that 7 and 18 miRNAs were defined as the sex-and age-specific miRNAs,respectively.The expression of miR-181c-5p,miR-20b-5p,miR-98b-5p,miR-329-3p,miR-341-5p,and

miR-2137

showed significant age-difference in mice thymus by quantitative polymerase chain reaction.High expression levels of miR-2137 were detected in mice thymic epithelial cells and gradually increased during the process of thymus aging.MiR-27b-3p and miR378a-3p of the female-biased miRNAs were confirmed as the sex-and estrogen-responsive miRNAs in mice thymus in vivo.Their potential target genes and the pathway were identified by the online software.Possible regulation roles of sex-and age-specific miRNA expression during the

process of thymus aging were discussed.Our results suggested that these miRNAs may be potential biomarkers for the study of sex-and age-specific thymus aging and involution. 【总页数】11页(409-419) 【关键词】

【作者】Dongguang Guo;Yaqiong Ye;Junjie Qi;Xiaotong Tan;Yuan Zhang;Yongjiang Ma;Yugu Li

【作者单位】Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China;Department of Basic Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan 528000, China;Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China;Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China;Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China;Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China;Department of Basic Veterinary Medicine, College of Veterinary Medicine, South China Agricultural University,Guangzhou 510642, China 【正文语种】英文

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