Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through p

Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly

佚名

【期刊名称】《中国科学》 【年(卷),期】2010(000)011

【摘要】Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity. Live cell imaging showed that some paclitaxel-treated cells accomplished multipolar cell division and a portion of the daughter cells went on to the next round of mitosis. The surviving cells grew into clones with varied genome content. The results indicated that an aneuploidy population could be induced by short exposure to paclitaxel at a low dose, implicating potential side effects of paclitaxel.

【总页数】8页(P.1322-1329)

【关键词】paclitaxel;tpx2;Aurora-A;multipolar;cell;division;aneuploidy 【作者】佚名 【作者单位】; 【正文语种】英文