CCLG-2008方案治疗标危中危儿童急性淋巴细胞白血病中
期随访结果
刘晓明;邹尧;王慧君;陈晓娟;阮敏;陈玉梅;杨文钰;郭晔;刘天峰
【期刊名称】《中华儿科杂志》 【年(卷),期】2014(052)006
【摘要】Objective To estimate the significance of the adjustment of acute lymphoblastic leukemia (ALL) risk group by monitoring minimal residual disease(MRD).Method Totally 285 children ALL patients who were diagnosed and systematically treated according to CCLG-2008 in Institute of Hematology and Blood Diseases Hospital,CAMS and PUMC,from
April
2008
to
August
2011
were
prospectively
selected.Among these cases,62.8％ (n =179) were boys and 37.2％ (n =106) were girls and the median age was 5.3 (0.5-14.0).The patients who were at high-risk group initially were excluded.The grouping of eases:the patients were divided into two groups according to the dates of initial diagnosis.Group Ⅰ had 126 patients who were initially diagnosed between April 2008 and December 2009 in whom therapeutic regimen was not adjusted by reassignment of risk group by MRD.Group Ⅱ had 159 patients who were initially diagnosed between January 2010 and August 2011 whose therapeutic regimen was adjusted by reassignment of risk group by MRD at specific time (33rd day of induction chemotherapy and 12 weeks after the beginning of
CCLG-2008方案治疗标危中危儿童急性淋巴细胞白血病中期随访结果
